Autologous pericardial pulmonary conduit with single point attached commissures in a sheep model.
نویسندگان
چکیده
OBJECTIVE For the surgical treatment of congenital heart disease and in Ross procedure a valved conduit is frequently required. Since homografts are not readily available in every country, a reliable alternative is needed. We developed a novel technique to construct a valved pulmonary conduit with single point attached commissures (SPAC) in a simple and fast way from a small strip of autologous pericardium, molded and briefly treated with glutaraldehyde. METHODS Autologous pericardial pulmonary conduit was constructed intraoperatively and implanted in pulmonary position in a beating heart in six sheep. The prosthesis size was 31 mm for all sheep and the construction time (including 10 min glutaraldehyde treatment) was 19.0+/-3.3 min. Implantation time and cardiopulmonary by-pass was 27.3+/-5.4 min and 40.5+/-7.7 min, respectively. The sheep were euthanized after 6 months (222.7+/-5.8 days) postoperatively. RESULTS In all sheep, the autologous pericardial valve was immediately competent. At sacrifice, the pericardial valve was pliable and competent in all cases with SPAC well anchored to the pericardial conduit wall. The maximum transvalvular gradient at implant and at sacrifice was 3.3+/-2.8 mmHg and 3.3+/-2.0 mmHg, respectively. CONCLUSIONS This novel autologous pericardial pulmonary conduit with SPAC can be reliably produced in a very short time intraoperatively before cardiopulmonary by-pass. The simplicity of construction, biocompatibility and freedom of stenosis or thrombosis makes this autologous pulmonary conduit especially useful for patients at locations where homografts are not readily available.
منابع مشابه
Letter to the Editor Human aortic bioprosthesis
We have read with the greatest interest the paper by Wolfgang A. Goetz et al. entitled Truly stentless molded autologous pericardial aortic valve prosthesis with single point attached commissures in a sheep model [1]. We congratulate the authors on their achievements in the development of valve bioprosthesis. Apparently an autologous valve prosthesis is the subject of thorough study in the Medi...
متن کاملFresh Pericardial Valved Conduit for Reconstruction of Right Ventricular Outflow Tract in Tetralogy of Fallot with Pulmonary Stenosis or Pulmonary Atresia—Early Results
Objective: To study early results of hand made fresh (autologous/homologous) pericardial valved conduit in achieving right ventricle to pulmonary artery continuity. Method: Between November 2014 and September 2015, 19 cases, with diagnosis of Tetralogy of Fallot with Pulmonary stenosis (PS) or Pulmonary atresia (PA) underwent intracardiac repair and Right Ventricular Outflow Tract (RVOT) recons...
متن کاملRadial artery versus saphenous vein as a second coronary bypass conduit in septuagenarians.
1269 We appreciate the interest of Siondalski et al. [1] and his group beside numerous other international groups in working on autologous aortic valve prosthesis. We experienced tremendous interest, especially in countries where patients need a priceless and reliable bioprosthesis without the need for anticoagulation and with advantageous hemodynamics especially in the smaller sizes. Siondalsk...
متن کاملPulmonary artery reconstruction using autologous pulmonary vein for surgical treatment of locally advanced lung cancer: a case report
BACKGROUND Resection and reconstruction of the pulmonary artery during lobectomy is a safe and effective procedure for centrally located lung cancer. We usually choose a pericardial conduit to repair a large defect of the pulmonary artery. The use of an autologous pulmonary vein conduit for reconstruction was first described in 2009. CASE PRESENTATION A 64-year-old woman with left upper lung ...
متن کاملReimplantation of an Anomalous Coronary Artery Arising from the Pulmonary Artery
A case of anomalous origin of the left coronary artery from the pulmonary artery in a patient with the origin of the coronary opposite to the aorta is reported. Between many surgical options we conclude to reestablish a double coronary system reconnecting the coronary through a conduit created with a pulmonary wall baffle and an autologous pericardial patch.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
دوره 33 1 شماره
صفحات -
تاریخ انتشار 2008